TorBUG meets on the last Wednesday of every month from September through April. Research presentations by bioinformatics leaders, students and industry representatives are followed by networking over pizza and refreshments.

Meetings are held in the Red Room at the Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street at 4:00 pm and are free and open to all.

Meeting Format:

4:00pm – 4:15pm Trainee Presentation (Red Room, Terrence Donnelly Centre)
4:15pm – 5:00pm Speaker Presentation (Red Room, Terrence Donnelly Centre)
5:00pm – 7:00pm Pizza and Beverage Session with Speaker and Bioinformatics community (Red Room, Terrence Donnelly Centre)

2015-2016 Season

Next Talk: September 30, 2015

4:00-5:00 - Main Event in CCBR Red Room
Trainee Speaker: Dr. Richard Jovelin (Awadalla Lab)
Talk Title: Worming evolutionary changes out of nematode genomes

Guest Speaker: Dr. Jo Knight, Associate Professor, CAMH
Talk Title: Fool's Gold? Identifying Genetic Variants that Play A Role in Complex Traits.

Abstract: When using genome wide association studies to identify variants that play a role in complex traits there are often only a few which reach the level of significance required to account for multiple testing. However, those that lie close to the threshold are likely to be enriched for true associated variants that we simply don't have the power to detect. The two methods I will discuss today are methods designed to identify the real gold from the fool's gold. In one we incorporate functional information relating to the variant such as epigenetic markers. In the other we incorporate knowledge of gene pathways.

Upcoming Speakers in 2015/2016:

September 30, 2015 – Jo Knight
October 28, 2015 – Alan Moses
November 25, 2015 – Alfonso Valencia
January 27, 2016 – Melissa Haendel
February 24, 2016 – Alex Bateman
March 30, 2016 – Joel Dudley
April 27, 2016 – Gary Bader

Past Speakers

  • Watch our past presentations on YouTube

Wednesday September 24, 2012

Speaker: Lincoln Stein, Director of Informatics and Bio-computing at the Ontario Institute for Cancer Research.
YouTube Presentation: modENCODE: The Good, the Bad and the "Uggh"

Short Presentation: Marc Fiume, PhD Candidate in Computer Science, Brudno Lab, University of Toronto.
YouTube Presentation: Next-generation genome browsing

Wednesday October 31, 2012

Speaker: Brian O'Connor
YouTube Presentation: Hack a What? Doing bioinformatics the Hack-a-thon Way

Speaker: Robin Haw
YouTube Presentation: Google Summer of Code: Bringing Google to Bioinformatics

Short Presentation: Yue Dong
YouTube Presentation: My Experience in the Google world

Speaker: Jean Lozach, Senior Scientist at Illumina Bioinformatics.
YouTube Presentation: BASE Space: Open Tools in the Cloud

Wednesday November 28, 2012

Speaker: Lars Jorgensen, Director of Genome Informatics, Personalized Genomics & Innovative Medicine at Mount Sinai Hospital.
Title: Bioinformatics in a Clinical Setting

Short Presentation: Omar Wagih, Masters Student in Computer Science, Bader Lab, University of Toronto
Title: SGATools: tools for image analysis, normalization and scoring SGA screens

Wednesday January 30, 2013

Speaker: Michael Brudno, Director, Centre for Computational Medicine, Hospital for Sick Children & Associate Professor, University of Toronto.
Title: Analyzing and Visualizing High Throughput Sequencing Data

Short Presentation: Leopold Parts, Research Associate, Boone & Andrews Labs, University of Toronto
Title: How come I have my father's nose? Quantitative genetics of protein traits.

Wednesday February 27, 2013

Speaker: Fritz Roth, Senior Scientist, Samuel Lunenfeld Research Institute and Canada Research Chair in Integrative Biology.
Title: 1) Pointing to causal genes on a prix fixe GWAS menu, and 2) protein network mapping via wild sex and sequencing
Short Presentation: Juri Reimand, Postdoctoral Fellow in Bader Lab, University of Toronto
Title: Chasing cancer drivers in cell signalling networks

Wednesday March 27, 2013

Speaker: Sara Diamond, President and Vice-Chancellor, OCAD University.
Title: Information and Scientific Visualization: Experiments in Aesthetics, Meaning and Process
Short Presentation: Jamie Waese, PhD Candidate, Department of Cell & Systems Biology, University of Toronto
Title: Building Data Visualization Tools for Large Biological Data Sets

Wednesday April 24, 2013, 4:00pm

Speaker: Dr. Wyeth Wasserman, Professor of Medical Genetics, Senior Scientist and Co-Director at CMMT at the University of British Columbia.
Title: Discovery of Regulatory Variations in Whole Genome Sequences
Short Presentation: Dr. Nuno Barbosa-Morais, Senior Postdoctoral Fellow, University of Toronto
Title: Studying the evolution of tissue-specific alternative splicing using RNA-Seq data

Wednesday September 25, 2013

Speaker: Brian Shoichet, Professor at Leslie Dan Faculty of Pharmacy, University of Toronto.
Title: The Metabolic Code
Short Presentation: Maria Safi, PhD Candidate, University of Toronto
Title: Efficient a priori modeling of drug resistance: structural models

Wednesday October 30, 2013

Speaker: Paul Boutros, Principal Investigator, Informatics and Bio-computing, OICR.
YouTube Presentation: World War B: Making Benchmarking Exciting

Short Presentation: Carl de Boer, PhD Candidate, University of Toronto
YouTube Presentation: Poly-dA:dT tracts form a directional nucleosomal turnstile in vivo

November 27, 2013

Speaker: Michael Hoffman, Princess Margaret Cancer Centre
YouTube Presentation: Semi-automated annotation of the human genome using chromatin and RNA-seq data

Short Presentation: Sarah Gagliano, Joanne Knight lab at CAMH
YouTube Presentation: A method to incorporate hundreds of functional characteristics with association evidence to improve SNP prioritization

January 29, 2014

Guest Speaker: Jared Simpson, Ontario Institute for Cancer Research
YouTube Presentation: Designing scalable algorithms for sequence analysis

Short Presentation: Lee Zamparo, Zhang Lab at University of Toronto
YouTube Presentation: Dimensionality reduction for high-content screening data

February 26, 2014

Guest Speaker: Guillaume Bourque, McGill University and Genome Quebec Innovation Center
Title: Mapping the functional elements in the human genome

Short Presentation: Oren Kraus, Frey Lab at University of Toronto
YouTube Presentation: Outlier Detection for High-Content Cell Screening

March 26, 2014

Guest Speaker: Michael Lawrence, Genentech
Title:Scalable and Integrative Genomics with R/Bioconductor

Short Presentation: David Shih, Taylor Lab at Sick Kids
YouTube Presentation: Investigating the molecular subgroups of medulloblastoma: means, motive and opportunity

April 30, 2014

Guest Speaker: Titus Brown, Michigan State University
YouTube Presentation: Building khmer, a platform for research in scalable sequence analysis

Short Presentation: Julio Diaz Caballero, David Guttman's lab at University of Toronto
YouTube Presentation: Periodic Selection Drives Pseudomonas aeruginosa Diversity in the Cystic Fibrosis Lung

September 24, 2014

Guest Speaker: Sandrine Dudoit, University of California Berkeley
YouTube Presentation: Normalization and Differential Expression in RNA-Seq

Short Presentation: Joseph O'Neill, University of Guelph
YouTube Presentation: Multi-locus GWAS analysis/genomic selection as a "clique" problem solved through evolutionary computation

October 29, 2014

Guest Speaker: Dr. Heng Li, Broad Institute
Title: Experimenting FM-index for multiple human samples

Short Presentation: Ladislav Rampasek, University of Toronto
Title: Probabilistic Method for Detecting Copy Number Variation in a Fetal Genome Using Maternal Plasma Sequencing

November 26, 2014

Guest Speaker: Dr. Mads Kaern, University of Ottawa
Title: Evidence for non-genetic causes of eukaryotic drug resistance

Short Presentation: David Kim, Cowen Lab, University of Toronto
Title: Investigating the Fungal Microbiome of Cystic Fibrosis Patient Lungs

January 28, 2015

Guest Speaker: Dr. Anna Goldenberg, University of Toronto
Title: Patient network-based framework for data integration in complex human diseases

Short Presentation: Amit Deshwar, Morris Lab, University of Toronto
Title: Reconstructing the evolutionary history of tumours

February 25, 2015

Guest Speaker: Dr. Benjamin Haibe-Kains, Princess Margaret Bioinformatics and Computational Genomics Laboratory
Title: Biomarker Discovery Using In Vitro Drug Sensitivity: The Good, the Bad and the Ugly

Short Presentation: Sunny Yu Liu, Wrana Lab, University of Toronto
Title: Translational bioinformatics: the key to precision medicine

March 25, 2015

Guest Speaker: Dr. Nicholas Provart, University of Toronto
Title: Raising the BAR for Integrative Biological Data Visualization Tools for Hypothesis Generation in Research and Education
Short Presentation: Dr. Mohammed Uddin, Scherer Lab, TCAG
Title: Integrated Genomic Approach to Identify Genes Associated with Developmental Delay

April 29, 2015

Guest Speaker: Dr. Paul Flicek, EMBL-EBI
Title: Evolutionary re-wiring: understanding transcriptional regulation using comparative regulatory genomics

Short Presentation: Dr. Ivan Borozan, Ferretti Lab, OICR
Title: Integrating alignment-based and alignment-free sequence similarity measures for biological sequence classification